Rejuran Classic
Often discussed for broader facial skin quality, including fine texture, dehydration and an overall loss of resilience.
Broader facial skin planningRejuran Skin booster
Rejuran Sydney | Chatswood and Hurstville
Rejuran Sydney: Skin Quality, Texture and Under-Eye Treatment
Sometimes the face does not need more volume or a stronger lift. The concern is the skin itself: fine crepiness, rough texture, dehydration, a tired eye area or skin that no longer seems to bounce back as it once did.
Rejuran is an injectable polynucleotide treatment considered for gradual improvement in skin quality. At Medical Aesthetics 360, the starting point is not simply choosing a product. It is working out whether the change you notice comes from the skin surface, scarring, pigmentation, laxity or deeper volume loss, because each needs a different plan.
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Main focusSkin quality rather than facial shape
Common areasFace, under-eyes and selected scars
ChangeGradual rather than instant
LocationsChatswood and Hurstville
A skin-first approach
What Makes Rejuran Different?
Rejuran belongs to a group of treatments made with polynucleotides. It is generally chosen to support the appearance and behaviour of the skin over time, rather than to replace lost facial volume or reshape a feature.
Researchers propose that polynucleotides may influence repair signalling and the environment around skin cells. That biological explanation is useful, but it is not the same as a guaranteed clinical result. Human studies remain relatively small, which is why realistic assessment matters.
Think textureRoughness, fine crepiness and uneven surface quality.
Think resilienceSkin that appears thin, dry or less supple.
Not facial sculptingIt is not primarily intended to create projection or replace volume.
Not an instant finishChanges are usually assessed over time and across reviews.
Understanding the treatment
What Are Polynucleotides?
Polynucleotides are long chains of nucleotides, the small building blocks found in DNA. In aesthetic medicine they are placed into selected areas of skin with the aim of supporting gradual improvement in qualities such as texture, elasticity and hydration.
This is different from using a treatment mainly to occupy space beneath the skin. Rejuran may be more relevant when the concern is fine surface change, while hollowness, deeper folds or significant laxity may require another approach.
The distinction is important around the eyes. Fine, crepey skin and true under-eye hollowing can exist together, but they are not the same problem and do not automatically need the same treatment.
Choosing by area and concern
Rejuran Classic, Rejuran i and Rejuran s
The names are less important than the job each option is being asked to do. Selection depends on the treatment area, skin thickness and the nature of the concern.
Rejuran i
Designed for delicate periocular skin, where fine crepiness or texture is more important than deeper under-eye hollowing.
Fine eye-area skin concernsRejuran s
May be considered for focal roughness and selected scar-related concerns after the scar type and depth have been assessed.
Targeted texture and scar planning
Treat the right problem
When Rejuran May Fit, and When It May Not
A good consultation sometimes leads to Rejuran, sometimes to a combined plan, and sometimes to a different treatment entirely.
Fine, Crepey or Dehydrated Skin
Rejuran may be relevant when the concern is subtle surface quality and the preference is gradual change rather than facial reshaping.
Under-Eye Concerns
Fine skin may suit a skin-quality approach. Pronounced hollowness, eye bags or pigmentation need separate assessment because they arise from different structures.
Acne Scars and Rough Texture
Scar depth and shape matter. Rejuran s may form one part of a plan, while tethered, boxcar or ice-pick scars may need release, resurfacing or device-based treatment.
Laxity or Volume Loss
Rejuran does not replace treatment designed for significant looseness, deeper folds or loss of structural support. Those concerns call for a different conversation.
Recovery and safety
What the First Few Days Can Look Like
Rejuran is placed through multiple small injections. Small raised bumps, redness and tenderness are therefore expected immediately afterwards and usually settle. Bruising and swelling can also occur, particularly around the eyes, where even modest swelling is more noticeable.
Recovery is individual. It is sensible to avoid scheduling treatment immediately before an important event and to follow the aftercare instructions given for your treatment area.
As with any injectable procedure, less common complications can include infection, prolonged inflammation, nodules, allergic reaction or vascular injury. Your medical history, skin condition, previous procedures and current medications should be reviewed before treatment.
From consultation to review
What to Expect From a Rejuran Treatment Plan
There is no universal schedule that suits every face, product and concern. The number and spacing of sessions should be explained as part of your individual plan.
01
Identify the Concern
Your clinician examines skin quality, eye-area anatomy, scar pattern and treatment history to decide whether the issue is truly skin-led.
02
Select the Approach
If Rejuran is suitable, the product type, treatment area, session plan, costs, alternatives and expected downtime are discussed before consent.
03
Review the Response
Results are judged after early swelling has settled and the skin has had time to respond. Further treatment should depend on progress, not a fixed promise.
Evidence in context
What Does the Research Actually Say?
A 2025 systematic review identified nine clinical studies involving 219 patients. Several reported improvements in wrinkles, texture and elasticity, with side effects generally described as mild and temporary. That is encouraging, but the studies used different products, injection methods, areas and outcome measures.
The reviewers rated the available studies as low to moderate quality and concluded that better, larger trials are still needed. In practical terms, polynucleotides are promising, but claims should remain measured and no individual result can be predicted from the research alone.
The balanced takeaway
There is a plausible biological rationale and a growing body of positive clinical evidence, but no settled consensus on the ideal product, schedule or technique. Read the systematic review of polynucleotides in aesthetic medicine on PubMed.
Common questions
Rejuran Treatment FAQ
Practical answers for patients considering Rejuran in Chatswood or Hurstville.
Is Rejuran a volumising treatment?
Rejuran is generally selected for skin quality rather than facial projection or contour. If the main issue is deeper volume loss, another treatment assessment may be more appropriate.
What is the difference between Rejuran Classic, i and s?
Classic is commonly considered for broader facial skin quality, Rejuran i for delicate periocular skin, and Rejuran s for targeted texture or selected scar concerns. Final selection depends on examination and product suitability.
Can Rejuran i treat under-eye hollowness?
It is aimed at fine eye-area skin rather than replacing deeper volume. Crepiness, hollowness, pigmentation and eye bags can overlap, so the dominant cause needs to be identified first.
Can Rejuran help acne scars?
Rejuran s may be considered for selected texture concerns, but acne scars are not one uniform problem. Deeper or tethered scars often need a procedure chosen for their shape and depth, sometimes in a staged plan.
How many Rejuran sessions will I need?
There is no single schedule supported across every polynucleotide product and treatment area. Your plan should reflect the concern, skin response, downtime and review findings.
When should I expect to see a change?
Rejuran is usually approached as a gradual treatment. Early swelling is not the final result, and meaningful review takes place after the skin has settled and had time to respond.
How long do the small bumps last?
Visible injection bumps often settle over the following days, but timing varies by area, technique and individual response. Eye-area swelling may be more noticeable even when mild.
Can Rejuran be combined with lasers or skin tightening?
Sometimes, but combination treatment should have a clear reason and sensible timing. Texture, scarring, pigmentation and laxity respond to different tools, and doing more at once is not automatically better.
Explore related care
Related Skin Treatments and Sydney Clinics
Compare options according to the concern you are trying to solve, then find the Medical Aesthetics 360 location most convenient for you.
Suitability, alternatives, expected recovery and risks are confirmed during an individual consultation. Results and recovery vary between patients.